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1

Applications of chemogenomic library screening in drug discovery

Jones, Lyn H., Bunnage, Mark E.

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 477 KB

english, 2017

2

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

David J. Rawson, Stephen Ballard, Christopher Barber, Laura Barker, Kevin Beaumont, Mark Bunnage, Susan Cole, Martin Corless, Stephen Denton, David Ellis, Marion Floc’h, Laura Foster, James Gosset, Fr

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.28 MB

english, 2012

3

Total Synthesis of Brevetoxin A: Part 3: Construction of GHIJ and BCDE Ring Systems

K. C. Nicolaou, Guo-qiang Shi, Janet L. Gunzner, Peter Gärtner, Paul A. Wallace, Michael A. Ouellette, Shuhao Shi, Mark E. Bunnage, Konstantinos A. Agrios, Chris A. Veale, Chan-Kou Hwang, John Hutchin

Journal:

Chemistry - A European Journal

Year:

1999

Language:

english

File:

PDF, 407 KB

english, 1999

4

Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

K. C. Nicolaou, Mark E. Bunnage, Daniel G. McGarry, Shuhao Shi, Patricia K. Somers, Paul A. Wallace, Xin-Jie Chu, Konstantinos A. Agrios, Janet L. Gunzner, Zhen Yang

Journal:

Chemistry - A European Journal

Year:

1999

Language:

english

File:

PDF, 470 KB

english, 1999

5

Total Synthesis of Brevetoxin A: Part 2: Second Generation Strategy and Construction of EFGH Model System

K. C. Nicolaou, Paul A. Wallace, Shuhao Shi, Michael A. Ouellette, Mark E. Bunnage, Janet L. Gunzner, Konstantinos A. Agrios, Guo-qiang Shi, Peter Gärtner, Zhen Yang

Journal:

Chemistry - A European Journal

Year:

1999

Language:

english

File:

PDF, 252 KB

english, 1999

6

Endiine durch Retro-Diels-Alder-Reaktion

Dr. Mark E. Bunnage, Prof. Dr. K. C. Nicolaou

Journal:

Angewandte Chemie

Year:

1996

Language:

german

File:

PDF, 412 KB

german, 1996

7

Enediyne Generation by a Retro-Diels–Alder Reaction

Dr. Mark E. Bunnage, Prof. Dr. K. C. Nicolaou

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 402 KB

english, 1996

8

Total Synthesis of Balanol and Designed Analogues

Prof. Dr. K. C. Nicolaou, Kazunori Koide, Dr. Mark E. Bunnage

Journal:

Chemistry - A European Journal

Year:

1995

Language:

english

File:

PDF, 1.66 MB

english, 1995

9

The Oxide Anion Accelerated Retro-Diels-Alder Reaction

Mark E. Bunnage, K. C. Nicolaou

Journal:

Chemistry - A European Journal

Year:

1997

Language:

english

File:

PDF, 564 KB

english, 1997

10

ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 2. Second Generation Strategy and Construction of EFGH Model System.

K. C. Nicolaou, Paul A. Wallace, Shuhao Shi, Michael A. Ouellette, Mark E. Bunnage, Janet L. Gunzner, Konstantinos A. Agrios, Guo-qiang Shi, Peter Gaertner, Zhen Yang

Journal:

Year:

1999

File:

PDF, 28 KB

1999

11

ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 1. First Generation Strategy and Construction of BCD Ring System.

K. C. Nicolaou, Mark E. Bunnage, Daniel G. McGarry, Shuhao Shi, Patricia K. Somers, Paul A. Wallace, Xin-Jie Chu, Konstantinos A. Agrios, Janet L. Gunzner, Zhen Yang

Journal:

Year:

1999

File:

PDF, 30 KB

1999

12

Asymmetric Synthesis of the Putative Structure of (-)-Oryzoxymycin.

Mark E. Bunnage, Thota Ganesh, Ishmael B. Masesane, Darren Orton, Patrick G. Steel

Journal:

Year:

2003

File:

PDF, 5 KB

2003

13

Asymmetric Synthesis of the cis- and trans-Stereoisomers of 4-Aminopyrrolidine-3-carboxylic Acid and 4-Aminotetrahydrofuran-3-carboxylic Acid.

Mark E. Bunnage, Stephen G. Davies, Paul M. Roberts, Andrew D. Smith, Jonathan M. Withey

Journal:

Year:

2005

File:

PDF, 18 KB

2005

14

Asymmetric synthesis of the N-terminal component of microginin: (2S,3R)-3-amino-2-hydroxydecanoic acid, its (2R,3R)-epimer and (3R)-3-aminodecanoic acid

Mark E Bunnage, Anthony J Burke, Stephen G Davies, Christopher J Goodwin

Journal:

Tetrahedron: Asymmetry

Year:

1995

Language:

english

File:

PDF, 714 KB

english, 1995

15

Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol

Kazunori Koide, Mark E. Bunnage, Luigi Gomez Paloma, Joan R. Kanter, Susan S. Taylor, Laurence L. Brunton, K.C. Nicolaou

Journal:

Chemistry & Biology

Year:

1995

Language:

english

File:

PDF, 2.08 MB

english, 1995

16

The discovery of long acting β2-adrenoreceptor agonists

Alan D. Brown, Mark E. Bunnage, Paul A. Glossop, Kim James, Rhys Jones, Charlotte A.L. Lane, Russell A. Lewthwaite, Simon Mantell, Christelle Perros-Huguet, David A. Price, Mike Trevethick, Rob Webste

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 135 KB

english, 2007

17

The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists

Alan D. Brown, Mark E. Bunnage, Paul A. Glossop, Kim James, Rhys Jones, Charlotte A.L. Lane, Russell A. Lewthwaite, Simon Mantell, Christelle Perros-Huguet, David A. Price, Mike Trevethick, Rob Webste

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 118 KB

english, 2008

18

Highly potent and selective chiral inhibitors of PDE5: An illustration of Pfeiffer’s rule

Mark E. Bunnage, John P. Mathias, Anthony Wood, Duncan Miller, Stephen D.A. Street

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 634 KB

english, 2008

19

Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor

Dafydd R. Owen, David J. Bull, Mark E. Bunnage, Melanie S. Glossop, Robert J. Maguire, Ross S. Strang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 415 KB

english, 2010

20

Inhalation by design: Dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD

Lyn H. Jones, Helen Baldock, Mark E. Bunnage, Jane Burrows, Nick Clarke, Michele Coghlan, David Entwistle, David Fairman, Neil Feeder, Craig Fulton, Laura Hilton, Kim James, Rhys M. Jones, Amy S. Keny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 877 KB

english, 2011

21

An expeditious asymmetric synthesis of allophenylnorstatine

Mark E. Bunnage, Stephen G. Davies, Christopher J. Goodwin, Osamu Ichihara

Journal:

Year:

1994

Language:

english

File:

PDF, 965 KB

english, 1994

22

Asymmetric Michael additions of homochiral magnesium amides

Mark E. Bunnage, Stephen G. Davies, Christopher J. Goodwin, Iain A.S. Walters

Journal:

Tetrahedron: Asymmetry

Year:

1994

Language:

english

File:

PDF, 155 KB

english, 1994

23

The discovery of indole-derived long acting β2-adrenoceptor agonists for the treatment of asthma and COPD

Alan D. Brown, Mark E. Bunnage, Paul A. Glossop, Mark Holbrook, Rhys D. Jones, Charlotte A.L. Lane, Russell A. Lewthwaite, Simon Mantell, Christelle Perros-Huguet, David A. Price, Rob Webster

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 168 KB

english, 2007

24

New Frontiers in Chemical Biology Volume 870 || Chapter 7. Antibody–Drug Conjugates in Oncology

Bunnage, Mark E

Year:

2010

Language:

english

File:

PDF, 849 KB

english, 2010

25

ChemInform Abstract: Lead Diversification. Application to Existing Drug Molecules: Mifepristone 1 and Antalarmin 8.

M. Abid Masood, Elizabeth Farrant, Inaki Morao, Marc Bazin, Manuel Perez, Mark E. Bunnage, Sally-Ann Fancy, Torren Peakman

Journal:

Year:

2012

File:

PDF, 42 KB

2012

26

Acidic triazoles as soluble guanylate cyclase stimulators

Lee R. Roberts, Paul A. Bradley, Mark E. Bunnage, Katherine S. England, David Fairman, Yvette M. Fobian, David N.A. Fox, Geoff E. Gymer, Steven E. Heasley, Jerome Molette, Graham L. Smith, Michelle A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 417 KB

english, 2011

27

Lead diversification. Application to existing drug molecules: Mifepristone 1 and antalarmin 8

M. Abid Masood, Elizabeth Farrant, Inaki Morao, Marc Bazin, Manuel Perez, Mark E. Bunnage, Sally-Ann Fancy, Torren Peakman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

28

Lead Diversification 2: Application to P38, gMTP and lead compounds

M. Abid Masood, Marc Bazin, Mark E. Bunnage, Andrew Calabrese, Mark Cox, Sally-Ann Fancy, Elizabeth Farrant, David W. Pearce, Manuel Perez, Laure Hitzel, Torren Peakman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 668 KB

english, 2012

29

Total Synthesis of Balanol

Nicolaou, K. C., Bunnage, Mark E., Koide, Kazunori

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 288 KB

english, 1994

30

Inhalation by Design: Novel Tertiary Amine Muscarinic M 3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Glossop, Paul A., Watson, Christine A. L., Price, David A., Bunnage, Mark E., Middleton, Donald S., Wood, Anthony, James, Kim, Roberts, Dannielle, Strang, Ross S., Yeadon, Michael, Perros-Huguet, Chri

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.86 MB

english, 2011

31

Asymmetric synthesis of the cis- and trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid

Bunnage, Mark E., Davies, Stephen G., Roberts, Paul M., Smith, Andrew D., Withey, Jonathan M.

Journal:

Organic & Biomolecular Chemistry

Year:

2004

Language:

english

File:

PDF, 638 KB

english, 2004

32

Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease

Millan, David S., Bunnage, Mark E., Burrows, Jane L., Butcher, Kenneth J., Dodd, Peter G., Evans, Timothy J., Fairman, David A., Hughes, Samantha J., Kilty, Iain C., Lemaitre, Arnaud, Lewthwaite, Russ

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.41 MB

english, 2011

33

Kinetic resolution of tert-butyl (RS)-3-alkylcyclopentene-1-carboxylates for the synthesis of homochiral 3-alkyl-cispentacin and 3-alkyl-transpentacin derivatives

Bunnage, Mark E., Davies, Stephen G., Parkin, Richard M., Roberts, Paul M., Smith, Andrew D., Withey, Jonathan M.

Journal:

Organic & Biomolecular Chemistry

Year:

2004

Language:

english

File:

PDF, 915 KB

english, 2004

34

Target validation using chemical probes

Bunnage, Mark E, Chekler, Eugene L Piatnitski, Jones, Lyn H

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 757 KB

english, 2013

35

Inhalation by Design: Novel Ultra-Long-Acting β 2 -Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfonamide Agonist Headgroup

Glossop, Paul A., Lane, Charlotte A. L., Price, David A., Bunnage, Mark E., Lewthwaite, Russell A., James, Kim, Brown, Alan D., Yeadon, Michael, Perros-Huguet, Christelle, Trevethick, Michael A., Clar

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

36

Asymmetric synthesis of (1R,2S,3R)-3-methylcispentacin and (1S,2S,3R)-3-methyltranspentacin by kinetic resolution of tert-butyl (�)-3-methylcyclopentene-1-carboxylateThis is one of a number of contributions from the current members of the Dyson Perrins Laboratory to mark the end of almost 90 years of organic chemistry research in that building, as all its current academic staff move across South Parks Road to a new purpose-built laboratory.

Bunnage, Mark E., Chippindale, Ann M., Davies, Stephen G., Parkin, Richard M., Smith, Andrew D., Withey, Jonathan M.

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 310 KB

english, 2003

37

New Frontiers in Chemical Biology || Subject Index

Bunnage, Mark E

Year:

2010

Language:

english

File:

PDF, 92 KB

english, 2010

38

New Frontiers in Chemical Biology || Front Matter

Bunnage, Mark E

Year:

2010

Language:

english

File:

PDF, 75 KB

english, 2010

39

New Frontiers in Chemical Biology || Contents

Bunnage, Mark E

Year:

2010

Language:

english

File:

PDF, 64 KB

english, 2010

40

New Frontiers in Chemical Biology || Preface

Bunnage, Mark E

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

41

New Frontiers in Chemical Biology || Chapter 6. Chemologics

Bunnage, Mark E

Year:

2010

Language:

english

File:

PDF, 3.10 MB

english, 2010

42

Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction

Allsopp, Timothy E., Bunnage, Mark E., Fish, Paul V.

Journal:

Year:

2010

Language:

english

File:

PDF, 490 KB

english, 2010

43

Getting pharmaceutical R&D back on target

Bunnage, Mark E

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 385 KB

english, 2011

44

Asymmetric Synthesis of the Putative Structure of (−)-Oryzoxymycin

Bunnage, Mark E., Ganesh, Thota, Masesane, Ishmael B., Orton, Darren, Steel, Patrick G.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 67 KB

english, 2003

45

Discovery of Potent & Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor for the Treatment of Thrombosis

Bunnage, Mark E., Blagg, Julian, Steele, John, Owen, Dafydd R., Allerton, Charlotte, McElroy, Andrew B., Miller, Duncan, Ringer, Tracy, Butcher, Ken, Beaumont, Kevin, Evans, Karen, Gray, Andrew J., Ho

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 223 KB

english, 2007

46

Crystal Structure of the Potent Natural Product Inhibitor Balanol in Complex with the Catalytic Subunit of cAMP-Dependent Protein Kinase †

Narayana, Narendra, Diller, Thomas C., Koide, Kazunori, Bunnage, Mark E., Nicolaou, K. C., Brunton, Laurence L., Xuong, Nguyen-Huu, Ten Eyck, Lynn F., Taylor, Susan S.

Journal:

Year:

1999

Language:

english

File:

PDF, 169 KB

english, 1999

47

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Fish, Paul V., Filippakopoulos, Panagis, Bish, Gerwyn, Brennan, Paul E., Bunnage, Mark E., Cook, Andrew S., Federov, Oleg, Gerstenberger, Brian S., Jones, Hannah, Knapp, Stefan, Marsden, Brian, Nocka,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.91 MB

english, 2012

48

Asymmetric synthesis of anti-(2S,3S)- and syn-(2R,3S)-diaminobutanoic acidThis is one of a number of contributions from the current members of the Dyson Perrins Laboratory to mark the end of almost 90 years of organic chemistry research in that building, as all its current academic staff move across South Parks Road to a new purpose-built laboratory.

Bunnage, Mark E., Burke, Anthony J., Davies, Stephen G., Millican, Nicholas L., Nicholson, Rebecca L., Roberts, Paul M., Smith, Andrew D.

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 218 KB

english, 2003

49

Asymmetric synthesis of homochiral syn- and anti-3-phenylisoserine derivatives: a practical strategy for the synthesis of the taxol C-13 side chain

Bunnage, Mark E., Davies, Stephen G., Goodwin, Christopher J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1993

Language:

english

File:

PDF, 255 KB

english, 1993

50

Asymmetric synthesis of ?-amino-?-hydroxy acids via diastereoselective hydroxylation of homochiral ?-amino enolates

Bunnage, Mark E., Chernega, Alexander N., Davies, Stephen G., Goodwin, Christopher J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1994

Language:

english

File:

PDF, 1.72 MB

english, 1994